2型糖尿病治疗的新选择——DPP-4抑制剂

王汝龙,母义明,胡欣

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (8) : 702-704.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (8) : 702-704. DOI: 10.11669/cpj.2014.08.021
知识介绍

2型糖尿病治疗的新选择——DPP-4抑制剂

  • 王汝龙1,母义明2,胡欣3
作者信息 +

The New Choice for the Treatment of Type 2 Diabetes——DPP-4 Inhibitors

  • WANG Ru-long1,MU Yi-ming2,HU Xin3
Author information +
文章历史 +

摘要

目的综述2型糖尿病(T2DM)的流行病学现状和基于肠促胰素的新型口服降糖药治疗应用。方法以近年来的研究文献为基础,对以西格列汀为代表的DPP-4抑制剂的作用机制、循证医学证据、指南地位等方面进行介绍。结果与结论大量临床研究证据表明,DPP-4抑制剂无论是单药还是联合治疗,都突显了其有别于传统药物的独特优势和价值,不仅可有效降糖,还具有良好的安全性。该类药物已获得一些学术机构的指南推荐。

Abstract

OBJECTIVE To review the epidemiological status of type 2 diabetes (T2DM) and therapeutic applications of incretin-based novel oral hypoglycemic agents. METHODS Based on the literatures in recent years, the mechanism and clinical evidence of DPP-4 inhibitors, particularly sitagliptin, in diabetes management were reviewed and introduced, especially sitagliptin. RESULTS AND CONCLUSION DPP-4 inhibitors have many advantages and a good future in diabetes care, as either monotherapy or combination therapy. DPP-4 inhibitors have good safety profile and are recommend by some academic organizations.

关键词

2型糖尿病 / 口服降糖药物 / 肠促胰素 / DPP-4抑制剂 / 西格列汀

Key words

type 2 diabetes / oral hypoglycemic agent / incretin / DPP-4 inhibitor / sitagliptin

引用本文

导出引用
王汝龙,母义明,胡欣. 2型糖尿病治疗的新选择——DPP-4抑制剂[J]. 中国药学杂志, 2014, 49(8): 702-704 https://doi.org/10.11669/cpj.2014.08.021
WANG Ru-long,MU Yi-ming,HU Xin. The New Choice for the Treatment of Type 2 Diabetes——DPP-4 Inhibitors[J]. Chinese Pharmaceutical Journal, 2014, 49(8): 702-704 https://doi.org/10.11669/cpj.2014.08.021
中图分类号: R95   

参考文献

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